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Discovery of direct inhibitors of Keap1-Nrf2 protein-protein interaction as potential therapeutic and preventive agents

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Experimental studies explore peptide signaling mechanisms, cellular regulatory pathways, and biological communication systems involving peptide fragments derived from larger hormone structures

Sublingual administration, which bypasses the gastrointestinal tract, appears to be equally effective as IM injections while being less invasive and more cost-efficientparticularly in patients with atrophic gastritis, post-gastrectomy status, or conditions that impair intrinsic factor-mediated absorption, where long-term intervention is often required

In contrast, in the obese ob/ob mice, both AOD9604 and hGH caused a pronounced decrease in body weight