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As a result, the olfactory region serves as a valuable route for delivering CNS-targeted therapies, particularly in the treatment of neurological disorders such as Alzheimer's disease, Parkinson's disease, epilepsy, migraine, and multiple sclerosis (Jeong et al., 2023)

32,153 The inhibition of mucociliary clearance by several specific moieties can induce congestion, dryness, irritation, and sneezing

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Even with daily injection doses of 1,000 g, the body absorbs only a fraction of this amount, with the rest being excreted in urine

By avoiding the use of oversimplified (and incorrect) terminology to describe these relationships and instead choosing more appropriate descriptive terms, the clinician will enhance the credibility of this important phenomenon and be better equipped to incorporate therapies that address the complexity of the whole stress response system

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