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Org Biomol Chem 19(18):39834001
Methylcobalamin 1500mcg Injection Uses Treats the deficiency of Vitamin B12 in the body

doi: 10.1016/j.cell.2012.03.042 33

This may indicate that the maximum capacity to methylate the catechol estrogens had been reached, resulting in some molecules to be channelled towards quinone and adduct formation