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118 Accumulation of fumarate inhibits the KDM5 family of histone demethylases, increasing the levels of the active gene transcription marker H3K4me3

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This symptom, known as jaundice, occurs when the body cannot remove bilirubin, a yellowish substance produced during the normal breakdown of red blood cells

Our study observed more increases in serum ammonia test ordering among patients with UCDs, cirrhosis with portal hypertension or decompensation, and compensated cirrhosis compared with patients with noncirrhotic CLD and CHF

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