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Additional effects include uncoupling of the electron transport chain to produce heat [185, 189]

Practical takeaway: Mild-to-moderate fluid loss can begin within the first hour or two of drinking, well before someone reaches a level of impairment where theyd think to compensate with water

This route combines the exploration of the Inca citadel with a hike to the Portada de Intipunku (also known as the Sun Gate), a historic and symbolic place that offers spectacular views of Machu Picchu and its surroundings

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