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Based Complem

doi: 10.3892/ol.2018.7893 36

J.Bano-OtaloraB.PaszekA.RogersN.GoncalvesC

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18 , 19 , 20 Furthermore, a high expression of STAT3 alters the cell cycle 21 , 22 and inhibits the apoptosis by upregulating anti-apoptotic signaling 23 , 24 in inflammation-associated CRC and other human cancers

In sum, the inflammatory, epigenetic, and metabolic regulation of cellular components and activities is the core event of environmental and genetic manipulations that link cell senescence to organismal ageing