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Conclusion The pathogenesis of RA is complicated and, currently, there is no treatment that can completely cure the disease

139 The acetate-polymalonate pathway A fourth route to synthesize plant 1,4-NQs, the acetate-polymalonate pathway (also referred to as the polyketide pathway), relies on CoA-linked acetate and malonate substrates, occurs throughout at least half a dozen unrelated families, 7 and is most notably responsible for the production of plumbagin (5-hydroxy-2-methyl-1,4-NQ), droserone (3,5-dihydroxy-2-methyl-1,4-NQ), 5- O -methyldroserone and 7-methyljuglone (Figure 2), as well as bis-1,4-NQs, such as chitranone and diospyrin (Figure 1b)

However, the dosing regimens need to be standardized before DFO could be implemented in the clinical setting (Farr and Xiong, 2021)

Mok YY, Atan MS, Yoke Ping C, et al

Liu W, Wang L, Liu C, Dai Z, Li T, Tang B