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this, in turn, leads to accentuated elevations in blood concentrations of tHcy and MMA, and exacerbation of neurological sequelae due to vitamin B-12 deficiency in the brain and peripheral nervous system To test these and other predictions, in addition to human studies, it will be important to develop better animal models with closer similarity to the physiologic and clinical features of vitamin B-12 deficiency than rodent models currently provide

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Digit Biomark

Infusion Glutathione (often with Vitamin C) is infused over 3060 minutes

Quantitative determination of ion distributions in bacterial lipopolysaccharide membranes by grazing-incidence X-ray fluorescence

Document dosing rationales (route, concentration, frequency) and use pilot results to set dose escalation or fixeddose arms in the main study