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Experimental study demonstrates that LDN induces a phenotypic shift in BV-2 microglial cells, transitioning them from a pro-inflammatory(iNOS high CD206 low ) to a quiescent, anti-inflammatory M2 state (iNOS low CD206 high ) [150]

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MYC-driven cancer cells exhibit enhanced glutamine utilization accompanied by increased expression of key glutaminolysis enzymes, including GLS1/GLS2 and GLUD1 178180

However, a persistent and significant gap exists between these promising in vitro results and reliable, predictable field-scale applications