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Pardali E, Goumans MJ, ten Dijke P (2010) Signaling by members of the TGF-beta family in vascular morphogenesis and disease

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As shown in Table 1, continuous application of DEC-containing serum led to a statistically significant and progressive improvement in skin dullness and sallowness

Its caused by fluid becoming trapped in tissue because the lymphatic system isnt clearing it efficiently

Noteworthy, only a few studies have paid attention to the effects of AGE and SAC on the main prooxidant enzymes (XO, NADPH oxidase, or COX), so the mechanisms involved in the possible inhibitory actions of these compounds have been not elucidated yet

That is a difference of three or four orders of magnitude in human evidence