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Method Enzymol 234:279293 [DOI] [PubMed] [Google Scholar] Rice-Evans CA, Miller NJ, Paganga G (1996) Structure-antioxidant activity relationships of flavonoids and phenolic acids

By converting phospholipid hydroperoxides into harmless alcoholic derivatives, GPX4 effectively inhibits membrane lipid peroxidation and suppresses ferroptotic cell death (118)

the *OH radical are most dangerous because they not only have a free electron, but also a negative charge so they will chemically bond with almost any compound, which results in a change of the shape and the function of the biochemical bound to the free radical

Similarly, a mouse model study showed that a reduction in mitochondrial DNA polymerase g (POLG) is linked to higher levels of mutations and more apoptotic markers relative to the control group with intact POLG expression levels (Lee and Wei, 1997

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