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doi: 10.1182/blood.V69.2.401.401 44 SiraskarB.BallalA.BobbalaD.FllerM.LangF

Cells were fixed with 4% PFA and nuclei were counterstained with 4,6-diamidino-2-phenylindole (DAPI), as described above

Alternatively, endocytosis and/or transcytosis of GSH transporter-targeted ligands may be assayed by in vivo bioimaging techniques using for instance near-infrared dyes or radioactive labels conjugated thereto, resulting in at least 10, 20, or 50% enhanced retention in CNS area of the ligand at given time-points (based on region of interest (ROI) pixel quantification), as compared to appropriate control conditions (e.g., comparison to reference compounds lacking GSH moieties)

The effect of intravenous ferric carboxymaltose on cardiac reverse remodelling following cardiac resynchronization therapythe IRON-CRT trial