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These include: receptor blocking strategies whereby putative alpha-synuclein receptors could be blocked inhibiting alpha-synuclein spread, an alpha-synuclein reduction which will decrease the amount alpha-synuclein available for aggregation and pathway disruption, the use of small molecules in order to target alpha-synuclein aggregation, immunotherapy and the increase of alpha-synuclein degradation by increasing autophagy/lysosomal flux

For more difficult cases, the drug Methacholine is used to make the diagnosis

Combined with multimodal neuroimaging, biomarker monitoring, and clinical assessment, this will help us stratify the risk of cognitive impairment and guide the individualized management of cognitive rehabilitation after COVID-19

Contemporary investigations concentrate on decoding the complex interplay between signal transduction networks, chromatin modifications, and microenvironmental cues that regulate ADSC functionality across diverse therapeutic applications

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Diab-Metab Res Rev