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Several examples have also now emerged suggesting the GH/IGF-1 signaling pathway is relevant to human aging 12 , including the discovery of functional mutations in the IGF-1R gene in individuals with exceptional longevity, resulting in relative IGF-1 resistance 13,14 , and in subjects lacking functional GH receptors (Laron dwarfs) 15

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Research shows NNMT inhibition dramatically improves how cells produce and utilize energy

Metformin-related vitamin B12 deficiency may cause or accelerate distal symmetrical and autonomic neuropathy in the patient with diabetes (35)

Confirm with a serum B12 test (below 300 pg/mL warrants supplementation