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The sample size for all experiments ( in vitro and in vivo ) was not chosen with consideration of adequate power to detect a prespecified effect size

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Corsaro, A., Paludi, D., Villa, V., DArrigo, C., Chiovitti, K., Thellung, S., Russo, C., Di Cola, D., Ballerini, P., Patrone, E., Schettini, G., Aceto, A., & Florio, T

Hepatology 40:11701179 Korman MG, Hofmann AF, Summerskill WH (1974) Assessment of activity in chronic active liver disease

278,279 In addition, this technology is used in the clinically approved vaccines ALC-0315 (BNT162b2-Comirnaty) and SM-102 (mRNA-1273-Spikevax), where the pKa value ranges from 6.1 to 6.7

Notably, CLR01 forms enclosed inclusion complexes with the lipid head groups of viral membranes, thereby altering lipid orientation and augmenting surface tension (Fig
