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Chronic hepatitis E is rare and mainly occurs in individuals with immune deficiencies or those using immunosuppressive drugs, akin to non-hepatotropic hepatitis mechanisms such as Epstein-Barr virus (Liu et al., 2024) and cytomegalovirus (Heusel et al., 2024)

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Lastly, the question of whether or not there is a mitochondrial (or other subcellular location)-specific transporter for ergothioneine is unresolved (Reference Kerley, McCarthy and Kell36)