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doi: 10.1186/s13024-017-0154-3

Its no wonder you often feel the consequences of one wild, booze-filled night even a few days after

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The antidepressant properties of Semax center on its ability to upregulate BDNF in specific brain areas

Activation of these receptors enhances burst firing in dopaminergic neurons, increases dopamine release in the nucleus accumbens, thereby forming rewarding signals for external stimuli such as nicotine ( 5 , 3 , and 4 subtypes similarly play negative regulatory roles in nicotine uptake and aversive effects ( FIGURE 2 The rewarding mechanism of nicotine addiction is closely linked to the subtype-specific functions and molecular diversity of nicotinic acetylcholine receptors (nAChRs), the core of which lies in the spatiotemporal regulation of neurotransmitter release by distinct nAChR subtypes within the mesolimbic dopamine system

[DOI] [PubMed] [Google Scholar] 197.Greaves M.W., Tan K.T