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GSH depletion as well as alterations of SAA metabolism are linked to a host of disease states including liver cirrhosis, various pulmonary diseases, myocardial ischemia and reperfusion injury, aging, Parkinson's disease, Alzheimer's disease, sepsis, and others

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doi:10.1038/s42003-025-07738-0

When your mucosal barrier is compromised, those tight junctions between cells in the intestinal walls open up, leading to small gaps where bacteria and other toxins can move freely
