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Description
1 XPO-1 inhibitor therapy The upregulation of XPO1 inactivates tumor suppressor anti-neoplastic function, facilitating the transport of tumor suppressor proteins from the nucleus to the cytoplasm

Additionally, it has been reported that the mitochondria regulate the stemness of non-malignant stem cells, and that altering the mitochondrial function dictates the acquisition and maintenance of stemness of non-cancerous cells [ In vivo applications [ There are several approaches to target the mitochondria, which can be classified as molecule- and nanocarrier-based targeting

& Cassilhas, R

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