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However, TGF- signaling can suppress AhR expression via methyl-CpG-binding domain 2 (MBD2) -mediated promoter methylation, potentially limiting the antifibrotic efficacy of Kyn [117]

Therefore, persistent interactions with misfolded or metastable proteins can overload the chaperone system, thereby ultimately compromising global protein homeostasis

DeFilippis AP, Chapman AR, Mills NL, de Lemos JA, Arbab-Zadeh A, Newby LK, et al

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[DOI] [PMC free article] [PubMed] [Google Scholar] Linciano S

This treatment is most often used in severe cases or in the event of myasthenic crisis