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Additionally, the amylin pathway might prove to be more tolerable than GLP-1, the analysts wrote

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Still, it raises an interesting question

But when the same receptor gets hit with the same signal nonstop, a chain of events unfolds: The cell marks the receptor with a chemical tag (phosphorylation) A protein called beta-arrestin grabs the tagged receptor and shuts down further signaling The cell pulls the receptor inside (internalization) Some receptors get recycled and put back on the surface

Kapur, R