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(2016) The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction

Data are represented as mean SEM

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In addition, astrocytes, which normally support neurons, become dysfunctional through a process called astrogliosis, which worsens glutamate imbalance and reduces neuronal support (Taylor et al., 2016), and genetic mutationssuch as SOD1 (causing harmful protein accumulation), FUS (interfering with RNA handling), and TBK1 or OPTN (which impair the cell's waste disposal system known as autophagy

[DOI] [PMC free article] [PubMed] [Google Scholar] 47.Beni F.A., Saffarfar H., Elhami A., Kazemi M

Giorgi C, Marchi S, Simoes ICM, Ren Z, Morciano G, Perrone M, et al