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Sunil, A

Pak J Pharm

It has also been reported that mitochondrial membranederived nanovesicles, by mimicking the natural process of mitochondrial transfer, can deliver drugs precisely to tumor mitochondria and synergistically induce cell death, thereby effectively inhibiting glioma [566]

ROS represent a double-edged sword in that normal levels of the free radicals are necessary for signaling and elimination of harmful microorganisms while excessive amounts can lead to cell proliferation in cancers and apoptosis

Thioredoxin regulation of the glucocorticoid receptor through association at the DNA binding domain has also been reported [34] and this too is influenced by ROS