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Nature 574 (7779), 575580

A NOEL was not identified (LOEL: 720 mg/m 3 ) (Appelman et al., 1982)

181 The interaction between certain proteins and copper also plays a role in tumor metastasis

Keenoy BM, Moorkens G, Vertommen J, De Leeuw I

Thus, copper is indispensable for cellular metabolism, particularly the mitochondrial respiratory chain [20, 23]
