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Neither has been tested in humans, and both carry significant unknowns -- Dihexa with its retracted publication and oncological pathway concerns, PE-22-28 with its untested cognitive effects and potential seizure susceptibility

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[DOI] [PMC free article] [PubMed] [Google Scholar] 168.Lech W., Sarnowska A., Kuczynska Z., Dabrowski F., Figiel-Dabrowska A., Domanska-Janik K., Buzanska L., Zychowicz M

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In the knockout mice, there was no significant decrease in body weight or lipolysis, thus indicating the importance of the beta-adrenergic pathways in weight loss