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Chronic dietary l-carnitine supplementation in mice altered cecal microbial composition, markedly enhanced synthesis of TMA and TMAO, and increased atherosclerosis, but this did not occur if intestinal microbiota was concurrently suppressed

This characteristic could be linked to the increased incidence of POI after chemotherapy 118

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Current integrated interventions for these psychological symptoms include psychotherapy (e.g., cognitive behavioral therapy), pharmacotherapy (e.g., antidepressants), neuromodulation techniques (e.g., transcranial magnetic stimulation), hyperbaric oxygen therapy, lifestyle modifications (e.g., exercise and sleep management), and social support and rehabilitation programs

Muscles formed by fast fibres tend to have a lower oxidative capacity, generate considerable energy from glycolysis and high-energy phosphate stores, being susceptible to rapid fatigue
