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Selenium was first discovered by the Swedish chemist Berzelius in 1817 in the tailings of sulfuric acid production and was long considered a toxic element

& Richter, G

3 , 4 , 5 , 6 , 7 , 8 An immunohistochemical study in a RP pig model suggested that the death of rods results in decreased oxygen consumption and hyperoxia in the outer retina resulting in gradual cone cell death from oxidative damage

found that curcumin reduced oxidative stress in rat pups [52]