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As oligodendrocytes are the primary iron-containing cells in the brain and play a crucial role in maintaining iron homeostasis for myelin synthesis through the expression of transferrin and ferritin [182], their degeneration can release excess iron into the local environment, potentially exacerbating oxidative damage and ferroptosis

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Metabolites 12(10):958 Zhang ZX, Zhou YJ, Gu P, Zhao W, Chen HX, Wu RY et al (2023) Exosomes derived from human umbilical cord mesenchymal stem cells alleviate Parkinsons disease and neuronal damage through inhibition of microglia

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osmolarity, 309 mosm

Endoneurial microangiopathy, characterized by capillary abnormalities, occurs early in DPN and correlates with clinical, neurophysiological, and morphological abnormalities
