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Hepatic glycine and pyruvate can be converted to glyoxylate and alanine via the action of the vitamin B6-dependent enzyme, alanineglyoxylate and serinepyruvate aminotransferase (encoded by the AGXT gene)

The signal changed less than 10% for standards prepared in MCTS extracts or in culture medium (Supplemental Figure 9), indicating that the matrix effect did not significantly affect the signal response of the target analyte Pt-DDTC

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[DOI] [PMC free article] [PubMed] [Google Scholar] 170.Benek O., Hroch L., Aitken L., Dolezal R., Guest P., Benkova M., Soukup O., Musil K., Kuca K., Smith T.K., et al

These sensations may extend up the arm and, in severe cases, can even lead to muscle atrophy or thinning of muscle mass in the thumb