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However, passive absorption may be well below 1% in many patients, 60 and high biliary B 12 excretion may add to a negative B 12 balance

J Histochem Cytochem (2021) 69(3):16576

In mouse models of type 2 diabetes induced by a highfat diet and streptozotocin, 4 weeks of 5amino1mq injection reduced fasting blood glucose by 25%30%, increased insulin secretion by over 20%, and significantly decreased cell apoptosis

I mention the bottom as I imagine it would hurt less

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One concern is that, if pre-cancerous cells are already present, very high availability of growth-supporting nutrients such as B12 could, in theory, support their growth too