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In chronic stress HPA models (CRS 14 days): BPC-157 reduces corticosterone AUC 2228% (vagal-NTS-PVN CRH arc)

[DOI] [PubMed] [Google Scholar] 73.Dhurat R., Sukesh M., Avhad G., Dandale A., Pal A., Pund P
GEMINI I TRIAL EXPLORATORY END POINTS TNF subgroup analyses compared with placebo Not powered for statistical significance

For microdosing, lower concentrations are almost always better

BPC 157 has been studied for anti-inflammatory effects, including modulation of cytokines and tissue-level inflammatory responses

Those who strictly adhere to a vegetarian or vegan diet may also be at risk for a vitamin B12 deficiency and need supplements or foods fortified with the vitamin
