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We thus cultured cells in media with L-cystine but without L-glutamate, media lacking L-cystine and L-glutamate, or media lacking L-cystine but supplemented with L-glutamate (i.e., mimicking system x c - activity)

Overall, our findings indicate an important neuroprotective role for GPX4 in neurons of the nigrostriatal pathway, and also suggest a role in neuromelanin synthesis associated with primate aging

This is supported by a study which found that the neuroprotective effects seen following oral administration of glutathione correlated with decreased oxidative stress