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Abrupt cessation wont cause withdrawal symptoms or rebound effects, but metabolic markers will gradually return to baseline over 24 weeks as AMPK activity normalizes and NNMT inhibition wears off

Injections should be administered following clinical assessment, and long-term or repeated use should be medically guided

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The most frequently reported adverse events (3%-10% of adult patients) following injection of BOTOX for severe primary axillary hyperhidrosis in double-blind studies include injection-site pain and hemorrhage, nonaxillary sweating, infection, pharyngitis, flu syndrome, headache, fever, neck or back pain, pruritus, and anxiety

Some doctors prescribe B12 shots for people with low B12 levels or conditions that make it hard to absorb B12 from foods and supplements