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Alternatively, in certain embodiments, T regulatory cells are depleted by anti-C25 conjugated beads or other similar method of selection

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The TCA cycle dynamics seemed to be time-dependent, with an apparent activation at 48 h preferentially supported by anaplerotic aromatic amino acids, leucine and lysine

This pathological mechanism involves the following sequential steps: 1) activation of the redox-sensitive metalloproteinase-9 (MMP9) by a redox dysregulation

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