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Abbreviations Ach: Acetylcholine AChR: Acetylcholine receptor ACON: Aconitate hydratase AI: Artificial intelligence ATP: Adenosine triphosphate ATPB: ATP synthase subunit B AUC: Area under curve CAD: Cis-aconitate decarboxylase CCC: Canadian consensus criteria CFS: Chronic fatigue syndrome CoQ10: Coenzyme Q10 CRAC: Calcium release activated channel ELISA: Enzyme-linked immunosorbent assay EV: Extracellular vesicle FM: Fibromyalgia GWI: Gulf-war illness HC: Healthy control IDO: Indoleamine 2,3-dioxygenase IFN-: Interferon alpha IOM: Institute of medicine IP 3 : Inositol triphosphate LDN: Low-dose naltrexone ME/CFS: Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome (ME/CFS) MS: Multiple sclerosis NK: Natural killer NKCC: Natural killer cell cytotoxicity NMR: Nuclear magnetic resonance NTX: Naltrexone hydrochloride PBMC: Peripheral blood mononuclear cell ROC: Receiver operating characteristic SNP: Single nucleotide polymorphism SWATH-MS: Sequential window acquisition of all theoretical fragment-ion spectra mass spectrometry TCA: Tricarboxylic acid cycle TOFMS: Time-of-flight mass spectrometry TRP: Transient receptor potential OR: -Opioid receptors References Esfandyarpour R, Kashi A, Nemat-Gorgani M, Wilhelmy J, Davis RW

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We performed a frequentist network meta-analysis to measure network estimates for the relative outcomes