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Additionally, gene editing and RNA-targeting technologies offer hope for transformative therapies, though challenges remain in ensuring specificity, safety, and long-term efficacy [5558]

Stimulation of Nrf2 by the lipid peroxidation product 4-hydroxy-2-nonenal (4-HNE) is involved in neuro- and cardio-protection against oxidative stress after ischemic preconditioning (Calvert et al., 2009

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