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Journal of Neuroscience , 38 , 90479058

Most of the error in such an approach arises from inaccurate differential solvation free energies of the acid and conjugate base which is removed in our approach using a correction based on the realization that the gas-phase acidities have only a small systematic error relative to the dominant systematic error in the differential solvation

People with very fair skin often carry MC1R gene variants (like R151C or R160W) that produce a receptor less responsive to melanocortin signaling