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If these pathways are more important than the rod oxygen demand, increasing the retinal oxygen tension could either have little effect, or might even accelerate the progression of diabetic retinopathy

They underwent a meta-analysis [3235, 4143]

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Notably, MnSOD levels in non-AD patients were found to be elevated in astrocytes, whereas in AD samples, this expression was significantly reduced

[110] Additionally, the delivery of a calcium/calmodulin-dependent protein kinase-IV (CAMK4) inhibitor via nanoparticles ameliorated murine SLE