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For systems that are strongly bound, this procedure will often result in an excessive overestimation of , especially in the absence of environmental influences (e.g., heat, light exposure, or electrical bias)

54,55 Similarly, in the mammary gland, Wnt signaling supports normal mammary stem cell proliferation and ductal morphogenesis, 56,57 and its dysregulation contributes to the expansion and tumorigenicity of breast CSCs

The interstitial GABA concentration in the islet is unknown, yet reason dictates that continuous exposure or frequent and higher dose GABA may be required for efficacy

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