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10.1016/j.actbio.2020.01.019 125 LushchakV

Unfortunately, the authors did not report brainstem results and did not conduct brainstem-specific analysis

The study period was March 1st, 2020 January 24, 2021
& Klauda, J
[DOI] [PubMed] [Google Scholar] 159.Sancho P, Bertran E, Caja L, Carmona-Cuenca I, Murillo MM, Fabregat I

The explanation for this discrepancy can be found in recent papers showing that some cancer cell linesincluding HCT116are not affected by L-BSO or GSH synthesis inactivation because they can compensate GSH depletion by the thioredoxin (TXN) pathway 25 , and by maintaining protein homeostasis through deubiquitinating enzymes (DUB) 32
