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Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation

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It was noted that Bacteriodetes microbes metabolize 3-oxolithocholic acid in bile salt to isoallolithocholic acid, which can enhance the differentiation of anti-inflammatory regulatory T (Treg) cells via epigenetic modulation [23]

IV glutathione has better absorption but requires recurring clinic visits and comes at higher cost

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