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Finally, is to be considered that the AMS involves central nervous system processes, altered cerebral blood flow, and neuroinflammation

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- Anti-Aging: Glutathione is the most important and effective endogenous antioxidant

doi: 10.1080/15384101.2019.1612698 284

Oct-Dec 2019;10(4):165-172

Also, reactive microglia produce quinolinic acid (Espey et al., 1997), an excitotoxic by-product of the tryptophan-kynurenine pathway, which has been implicated in the pathogenesis of central fatigue (Yamashita, 2020) and ME/CFS in particular (Kashi et al., 2019)