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Support a healthy concentration of nitric oxide, which helps endothelial cells relax and maintain blood flowsupporting proper blood pressure

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however, to appreciate the pathophysiological effects of LCACs, an understanding of LCAC origin is required

(Outlines contraindications for niacin therapy, including active peptic ulcer disease, active liver disease with elevated enzymes, hypersensitivity to niacin, and arterial bleeding, as well as monitoring recommendations for blood pressure, glucose, uric acid, etc., due to niacins systemic effects)

According to literature reviews, niosomes including 30 mg of Span 60 and cholesterol with 1: 1 molar ratio are efficient carriers for delivering drugs 64,65