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Animal study doses cannot be extrapolated to other species due to profound differences in melanocortin receptor expression, distribution, pharmacokinetics, metabolic rates, and species-specific neural circuit organization

doi: 10.3389/fimmu.2018.02648 86 Rosas-BallinaMGoldsteinRSGallowitsch-PuertaMYangLValdes-FerrerSIPatelNBet al

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Following ischemic stroke, activation of COX-2 and LOXs leads to excessive production of prostaglandins and leukotrienes, which amplify microglial activation, increase cytokine release, and promote further neuronal injury (Kloska et al., 2020