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In patients already receiving an opioid analgesic, prescribe a lower initial dose of the benzodiazepine or other CNS depressant than indicated in the absence of an opioid, and titrate based on clinical response

therefore, there is a need for improved therapeutic options [126]
A cannabigerol quinone alleviates neuroinflammation in a chronic model of multiple sclerosis

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"A serotonergic axon-cilium synapse drives nuclear signaling to alter chromatin accessibility"
