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Comprehensive literature analysis, the biosynthesis of CGA mainly depends on the following three key enzymes: Phenylalanine ammonia-lyase (PAL)/Shikimic acid/Quinic acid hydroxyl cinnamyl transferase (HCT), and Quinic acid cinnamate hydroxyltransferase (HQT)

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Interestingly, a small study on two older patients with mild depression explored the mechanism of acetyl-L-carnitines effects on depression

These effects are usually transient and rarely require discontinuation of therapy

Because the body only produces a limited amount of L-Carnitine on its own, supply can run short, particularly in people who eat little animal protein or have increased metabolic demands

doi: 10.1074/jbc.M114.595363 52 WaltA.KahnM