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doi: 10.1080/15548627.2023.2218764 69 ElseweidyMMHarbNGAliAAEl-AzizRMAElrashidyRA

GCH1-mediated BH4 synthesis reprograms lipid metabolism and inhibits ferroptosis by selectively preventing two polyunsaturated fatty acyl tails from depleting PLs (Kraft et al., 2020)

The approach is also compatible with the controlled production in stirred tank bioreactors as recently demonstrated for cardiac and hematopoietic lineages 77,78 and will provide the field with a potentially game-changing resource to allow the development of clinical as well as screening platforms where the requirement will be in the millions of organoids rather than todays laboratory scale

In addition to the effects of itaconate on macrophage functions, it is transported out of macrophages via the action of the ABCG2 encoded transporter

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