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The Master Detoxifier
Healthy blood urea levels (5.37-7.71 mM) increase significantly in end-stage renal disease to 18.75-26.25 mM [86,87]
Drugs 75, 157174
doi: 10.1016/j.neurobiolaging.2004.08.005
This dysfunction manifests as reduced vascular response to dilators (particularly to NO and prostacyclin), heightened pro-inflammatory responses leading to vascular wall inflammation, increased oxidative stress contributing to vascular damage, and pathological changes
doi: 10.1038/s41419-022-04770-4 149 ZhouXTangXLiTLiDGongZZhangXet al
