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Description
These antibodies feature dual Fc modifications: the YTE modification increases FcRn affinity and extends serum half-life, while L234F/L235E/P331S (collectively referred to as FES or TM mutations) reduces binding to Fc receptors and C1q in order to mitigate risk of antibody-dependent enhancement (ADE) (described in the LALA variant section)

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doi: 10.1016/j.molcel.2019.10.023 144 OuyangWWangSYanDWuJZhangYLiWet al

[DOI] [PMC free article] [PubMed] [Google Scholar] 25.Golding B.J., Overall A.D., Brown G., Gard P.R
& Hernandez, I
