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The deficiency can arise due to improper diet or the inability to absorb the vitamin through natural means

Wu et al
doi: 10.1128/mcb.13.10.6290

In general, efficient IN delivery to the CNS in humans can be achieved by optimizing the right combination of formulation delivery device, delivery volume, and head position to target specific nasal cavity regions [8]
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Severe Allergic Reaction (Anaphylaxis): Includes rash, severe itching, swelling of the face, throat, or tongue, or difficulty breathing